{"id":26,"date":"2021-07-02T11:11:54","date_gmt":"2021-07-02T02:11:54","guid":{"rendered":"https:\/\/hiro-ns.net\/en\/?page_id=26"},"modified":"2021-07-05T22:01:37","modified_gmt":"2021-07-05T13:01:37","slug":"department-of-neuroanatomy-2","status":"publish","type":"page","link":"https:\/\/hiro-ns.net\/en\/","title":{"rendered":"Grand Design of the Brain"},"content":{"rendered":"\n
How does the brain achieve higher-order functions such as cognition, thought, memory, and emotion? How does the disruption of the neuronal network cause neurological and psychiatric disorders? With the slogan “No structure, no function,” we are challenging these questions from a neuroanatomical standpoint.<\/div><\/div>\n\n\n\n
\"\"<\/figure><\/div>\n\n\n\n

In understanding the principle of how the brain works, it is essential to unravel its structural basis, the neuronal network. This is because there is no function without structure \u2013 form and function are inseparable (\u5f62\u80fd\u4e0d\u96e2<\/strong>).

We have analyzed the neuronal circuits of the central nervous system by morphological techniques with high spatial resolution. We have revealed that each neuron has a specific axonal projection and form specific synaptic connections to build neuronal networks rather than random connections. We are investigating neuronal circuits by focusing on the concept of “specificity<\/strong>,” which applies not only to the brain but also to all life phenomena. Neuronal circuit analysis using morphological methods, however, requires a lot of efforts and time. We are also engaged in the development of innovative bio-imaging tools<\/strong> to accelerate morphological analysis.

Based on the findings obtained from the morphological analysis, we are conducting cross-disciplinary research with collaborators in molecular biology, biochemistry, electrophysiology, behavioral science, and theoretical neuroscience, to elucidate the operating principles<\/strong> of the brain that realizes higher-order functions.<\/p>\n\n\n\n

<\/div>\n\n\n\n

Research Topics<\/span><\/strong><\/p>\n\n\n\n

\u25cf Neuronal Circuit Analysis of the Central Nervous System<\/strong>
\u3000Specific connections between neocortical inhibitory neurons
\u3000Projections of neostriatal neurons
\u3000Local circuits in the hippocampus
\u3000Reciprocal connections between the neocortex and thalamus
\u3000Projections of neuromodulatory neurons<\/p>\n\n\n\n

\u25cf Morphological Analysis of Mouse Disease Models<\/strong>
\u3000Mouse models for neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease)
\u3000Chronic psychological stress models<\/p>\n\n\n\n

\u25cf Development of innovative technologies for morphological analysis<\/strong>
\u3000Virus vectors (e.g. AAV, Sindbis virus, Adenovirus, and Lentivirus)
\u3000Development of new reporter proteins
\u3000Tissue-clearing technique
\u3000Correlative light and electron microscopy
\u3000Fluorescence signal amplification technique<\/p>\n\n\n\n

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